Biological radiation effects of carbon-14 and tritium labeled 5-fluorouracils.
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چکیده
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Synthesis of carbon-14 and tritium labeled sagamicin.
Sagamicin, an aminoglycoside antibiotic, was labeled with tritium by means of a platinum catalyzed hydrogen exchange reaction and by carbon-14 in two biosynthetic procedures. 14C-Methyl-L-methionine was used as the radioactive precursor in these biological processes involving Micromonospora sagamiensis. The distribution of radioactivity in 14C-sagamicin and gentamicin C1 was studied by mild aci...
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Cholera toxin was labeled with tritium by the Wilzbach technique, and highly purified radiolabeled toxin was obtained by Sephadex column chromatography and disc gel electrophoresis. 3H-labeled cholera toxin retained its biological activity and chemical stability and had a specific activity of 405.9 muCi/mumol. The methods utilized in extraction and purification of 3H-labeled toxin may be advant...
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In a n c,," method fo r prepar ing aldoses labeled wit h Lritium at ca r bon l , Lhc aldoni c lactone l S rcdu ced with li thium boro.hyddde-I in p yridine soluLion . The mcthod is suitablc for prcparing aldosesl -1 h a vin g high specifi c act ivit ies. Thc crudc product con tains a substant ia l proport ion of t hc c<?lTespondin g a ldi tol-l-I, but t he purc aldosc-l-1 is rcadil y scparated ...
متن کاملTritium - Labeled Compounds II . General - Purpose Appar - and Procedures Use of Tritium atus , and Lithium for the Preparation , Analysis , Oxide and Tritium - Labeled Borohydride
A general-purpose manifold is descd bed, which is useful for numerous proced ures involving trit ium gas and tritium-labeled mate rials. M ethods a re given in detail fOI' (a) converting t ritium gas to tritium oxide, (b) preparing tritium-labeled li thium borohy dride, and (c) conducting a variety of r eactions in a closed system. Auxilia ry equipment is shown, including water traps, reaction ...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1987
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.36.4_169